Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine Injection

Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats

The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) ...

Nicolau syndrome following intramuscular penicillin injection.

Nicolau Syndrome (NS) is a rare but severe localized adverse reaction at the site of intramuscular drug injection. The typical presentation is intense pain around the injection site soon after injection, followed by erythema, purplish network discolouration of the skin, haemorrhagic patch, and finally tissue necrosis. Here in, we report a 9 years old boy, the third Nicolau Syndrome (NS) reporte...

SERUM 6-hCG CONCENTRATION CHANGES FOLLOWING INTRAMUSCULAR hCG ADMINISTRATION

In circumstances such as in vitro fertilization (IVF) or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. At the same time, a question arises: How can a physician make sure that the β-hCG is of an endogenous source and not the residue of the prescribed drugs (hCG)? In this article we have studied the elimination time of 1M inject...

Quantitation of fluphenazine in equine serum following fluphenazine decanoate administration.

Fluphenazine, a potent antipsychotic used to treat schizophrenia in humans, is used in racehorses as a performance-enhancing drug, and for that reason it has been banned by the Association of Racing Commissioners International. A liquid chromatography-tandem mass spectrometry method for detecting and quantitating fluphenazine in equine serum was developed and validated. The method was then empl...

Primary and secondary leucocyte changes following the intramuscular injection of epinephrine hydrochloride.